Methyltrienolone (Metribolone): general information, effects.


Methyltrienolone is the strongest oral steroid ever produced. This drug is a close relative of Trenbolone and differs only in 17-alpha-alkylation. This modification makes it significantly more potent than Trenbolone. It is 120 to 300 times more potent than methyltestosterone. It is the strongest steroid available on the market, doses of 0.5 to 1 mg are enough for a strong anabolic effect. Its activity is accompanied by high toxicity, which limits its use in laboratory conditions.


Methyltrienolone was first described in 1965. It is one of the strongest anabolic steroids ever sold in pharmacies. This medicine has only been used in laboratory studies. There were studies on the treatment of breast cancer in the 1960s and 1970s. It slowed down and in some cases reversed the process of tumor growth. The studies did not last long due to the identified toxicity. In the mid-1970s, methyltrienolone was tested in animals to bind to androgen receptors. It was very suitable for this purpose.

Its activity and resistance to blood-binding proteins made it easily a reference substance. Due to their resistance to metabolism, methyltrienolone metabolites did not interfere with the results of most experiments.

Product shapes:

Methyltrienolone is not available as a prescription drug.

Structural properties:

Methyltrienolone is a modified nandrolone. It differs: 1) by the addition of a methyl group at position 17alpha, which allows protecting the drug orally, 2) by the introduction of a double bond between carbons 9 and 10, which reduces the bond and slows down the metabolism of the substance . As a result, we get a very potent steroid with a long half-life and low ability to bind blood proteins. Methyltrienolone differs from Trenbolone only by the addition of a methyl group at the c17-alpha position. This change alters the activity of the drug and cannot be called an oral analogue of trenbolone.

Estrogenic side effects:

Methyltrienolone does not aromatize and has no estrogenic activity. Dimethyltrienolone has an affinity for progesterone receptors. This can cause progesterone side effects such as stopping testosterone production and increasing body fat. Progestins also enhance the stimulating effect of estrogen on breast tissue growth. There is such a synergy that gynecomastia can be caused by progestin alone, without increasing estrogen levels. The use of antiestrogens can alleviate gynecomastia caused by the progestogen AAS.

Androgenic side effects:

Methyltrienolone is classified as an anabolic, but androgenic side effects are very possible. It could be an increase in oily skin, acne, hair growth on the body and face. Anabolic steroids can worsen hair loss in men. In addition, women should be aware of the potential virilizing effects of ASA. This can include a deepening of the voice, irregular menstruation, changes in skin structure, facial hair growth, and clitoral enlargement. Methyltrienolone does not react with 5α-reductase and its androgenicity cannot be altered by concomitant use of finasteride or dutasteride.

Side effects (hepatotoxicity):

Methyltrienolone is a c17-alpha-alkylated drug. This change protects the drug from liver inactivation, which means that a greater proportion of the drug enters the bloodstream after oral administration. Alkylated AAS can be hepatotoxic. Prolonged use or high doses can cause liver damage. In rare cases, life-threatening dysfunction may occur. It is advisable to consult a doctor regularly during the course to monitor liver function. Intake of alkylated AAS is usually limited to 6-8 weeks to avoid increased hepatic stress. Methyltrienolone is a very potent oral steroid and has a high level of resistance to liver metabolism. This makes it very toxic to the liver, which is why it was never sold in pharmacies. Research published in 1966 in Germany at the University of Bonn proved this. In fact, the researchers concluded that it was the most toxic drug for the liver: “Methyltrienolone … is an orally active drug, active at less than 1 milligram per day, whose effects on liver function have been tested.

Measurements were performed on several parameters: sulfbromolein retention, total bilirubin, transaminase activity, alkaline phosphatase, blood cholinesterase, blood plasma proaccelerin activity. According to the results of the effect on intrahepatic cholestasis, it can be said that methyltrienolone is the most hepatotoxic drug.
It may be appropriate to use liver-cleansing supplements such as Liver Stable, Life-52 and Essentiale Forte during the course.

Side effects (cardiovascular system):

AAS can have a harmful effect on blood cholesterol. It could be a decrease in the “good” HDL level, a shift in balance against atherosclerosis risk. The relative effect of ASA on lipids depends on the dose, route of administration, type of steroid and level of resistance to hepatic metabolism. Methyltrienolone has a greater negative effect on hepatic cholesterol control due to its non-aromatizing structure and mode of administration.

ASA can adversely affect blood pressure and triglycerides, reduce vascular endothelial relaxation, cause ventricular enlargement of the heart, potentially increasing the risk of cardiovascular disease and myocardial infarction. To reduce the load on the cardiovascular system, it is recommended to minimize the intake of saturated fats, cholesterol and simple carbohydrates during AAS. It is recommended to use dietary supplements such as fish oil, lipid stabilizer or similar products.

Testosterone suppression:

All AAS in doses needed for muscle building suppress endogenous testosterone production. Without the mixture of testosterone-boosting substances, testosterone will return to normal levels within 1-4 months after the cycle. Note that long-term hypogonadotropic hypogonadism can progress to secondary hypogonadism and requires medical attention.


Studies have shown that taking ASA orally with food reduces the bioavailability of the drug. This is due to the fat-soluble nature of ASA, which can cause some of the drug to dissolve in the fats in food, which will reduce the absorption of AAS in the gastrointestinal tract. For maximum effect, this medication should be taken on an empty stomach.

Reception (for men):

Methyltrienolone has not been approved for use in humans. This medication is not recommended for fitness purposes due to its high liver toxicity.

Those who really want to use this drug should take its toxicity seriously. Regular blood tests are needed to ensure that the drug does not harm the liver. The drug is not used for more than 4 weeks. For a clear anabolic effect, 0.5 mg of the drug is enough. Doses can range from 0.5 mg to 2 mg per day. It must be emphasized once again that there are many safer drugs. Methyltrienolone is a drug best left alone.

Reception (for women):

Methyltrienolone is not recommended for women due to its extremely strong toxicity and its tendency to cause virilization phenomena.

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